Culture, image formation, social and community issues have always interested her. In 2007, Karine Versluis completed her studies at the Koninklijke Academie van Beeldende Kunsten in The Hague with the publication of her book Staphorst about her birthplace. It shows how different generations live together and where traditions and modernity mix, an often returning theme in her work. In 2008 and 2009 she worked among other things at the project Enkeltje Schiphol – One Way Ticket to Schiphol Airport, among which an artist-in-residence at Insituto Buena Bista, the Curaçao Centre for Contemporary Art. In 2010, her book Enkeltje Schiphol arrived with the corresponding soloexhibition in the Nationaal Onderwijsmuseum in Rotterdam. In 2011 this exhibition can be seen at Imagine IC in Amsterdam.
In her work, she researches the influence that different cultures and historical happenings have on the daily life of people and how they deal with it. Versluis shows this through a caleidoscopic approach where she connects societal questions to the lives of individuals. With this, she researches the common grounds between art and anthropology.